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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Sargentodoxa cuneata (Oliv.) Rehd. et Wils.
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Sargentodoxa cuneata (Oliv.) Rehd. et Wils." in MCE Product Catalog:
6
Category:
Plants Fagaceae Dihydrochalcones Sweeteners Naphthalene Quinones Food Research Infection Quinones Flavonoids Vernicia fordii (Hemsl.) Airy Shaw Disease Research Fields
Target:
Cat. No.: HY-N0860
CAS No.: 64917-83-5
Synonyms: Schizantherin-E
Category:
Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.
Target:
Cat. No.: HY-N2297
CAS No.: 95298-47-8
Category:
Infection Triterpenes Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Disease Research Fields
Target:
Cat. No.: HY-N3832
CAS No.: 125072-69-7
Synonyms: (-)-Epinortrachelogenin
Target:
Category:
Quinones Flavonoids Vernicia fordii (Hemsl.) Airy Shaw Plants Fagaceae Dihydrochalcones Naphthalene Quinones
Target:
Cat. No.: HY-16638
CAS No.: 76849-19-9
Synonyms: PDDF
Target:
Domaines de recherche:
CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .
Cat. No.: HY-N10030
CAS No.: 126485-47-0
Target:
Cat. No.: HY-N13181
CAS No.: 213903-67-4
Target:
Cat. No.: HY-145889
CAS No.: 2495750-19-9
Target:
Domaines de recherche:
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
Cat. No.: HY-N17533
CAS No.: 1868129-15-0
Target:
Cat. No.: HY-115836
CAS No.: 118675-83-5
Target:
Domaines de recherche:
DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM .
Cat. No.: HY-N15535
CAS No.: 871720-22-8
Target:
Cat. No.: HY-N17524
CAS No.: 67517-03-7
Target:
Cat. No.: HY-N17571
CAS No.: 1176656-05-5
Category:
Target:
Cat. No.: HY-N3984
CAS No.: 295803-03-1
Target:
Cat. No.: HY-N17546
CAS No.: 861886-95-5
Target:
Cat. No.: HY-N17545
CAS No.: 861886-94-4
Target:
Cat. No.: HY-N17562
CAS No.: 1005390-47-5
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
